Significant suppression of radiation dermatitis in breast cancer patients using a topically applied adrenergic vasoconstrictor.

ABSTRACT:

Background

Our previous studies showed that vasoconstrictor applied topically to rat skin minutes before irradiation completely prevented radiodermatitis. Here we report on a Phase IIa study of topically applied NG12-1 vasoconstrictor to prevent radiodermatitis in post-lumpectomy breast cancer patients who received at least 40 Gray to the whole breast using standard regimens.

Methods

Patients had undergone surgery for Stage Ia, Ib, or IIa infiltrating ductal or lobular carcinoma of the breast or ductal carcinoma in situ. NG12-1 formulation was applied topically to the same 50-cm² treatment site within the radiation field 20 min before each daily radiotherapy fraction.

Results

Scores indicated significant reductions in radiodermatitis at the NG12-1 treatment

SUBMITTER: Cleary JF 

PROVIDER: S-EPMC5741935 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature