Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice.

ABSTRACT: BACKGROUND:Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked whether sex impacts the phenotypes of hyper- and hypothyroidism at two life stages. METHODS:Hyper- and hypothyroidism were induced by i.p. T4 or MMI/ClO4-/LoI treatment over 7 weeks in 12- and 20-months-old female and male C57BL/6N mice. Control animals underwent PBS treatment (n = 7-11 animals/sex/treatment). Animals were investigated for impact of sex on body weight, food and water intake, body temperature, heart rate, behaviour (locomotor activity, motor coordination and strength) and serum thyroid hormone (TH) status. RESULTS:Distinct sex impact was found in eu- and hyper

SUBMITTER: Rakov H 

PROVIDER: S-EPMC5741944 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature