Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: a cross-sectional study.

ABSTRACT:

Background

Early detection and treatment are the most important elements in reducing the incidence of melanoma deaths. Acquired melanocytic naevi (AMN) are well-known precursors of melanoma but most of our knowledge on the clinico-dermoscopic phenotypes of AMN is based on studies in European-background populations, particularly American and Australian populations. There has been little research in Chinese Han populations on clinico-dermoscopic variability of naevi or how naevi are affected by melanoma-linked variants of the melanocortin 1 receptor (MC1R) gene.

Methods

Clinical and dermoscopic features of 448 AMN in 115 patients from the Han ethnic group in mainland China were described. Germline polymorphisms in MC1R were determined for 98 of these patients.

SUBMITTER: Li X 

PROVIDER: S-EPMC5741976 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature