Deoxycholic Acid, a Metabolite of Circulating Bile Acids, and Coronary Artery Vascular Calcification in CKD.

ABSTRACT:

Background

Vascular calcification is common among patients with chronic kidney disease (CKD), and it is associated with all-cause and cardiovascular disease mortality. Deoxycholic acid, a metabolite of circulating bile acids, is elevated in CKD and induces vascular mineralization and osteogenic differentiation in animal models.

Study design

Cohort analysis of clinical trial participants.

Setting & participants

112 patients with moderate to severe CKD (estimated glomerular filtration rate, 20-45mL/min/1.73m²) who participated in a randomized controlled study to examine the effects of phosphate binders on vascular calcification.

Predictor

Serum deoxycholic acid concentration.

Outcomes

Baseline coronary artery calcification (CAC) volume score and

SUBMITTER: Jovanovich A 

PROVIDER: S-EPMC5742074 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature