Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury.

ABSTRACT: Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1^-/- ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1^-/- mice, and Pirfenidone was administered in food starting after 3 days. At 4 weeks, Pirfenidone reduced the appearance, on micro-computed tomography, of pitting in subchondral bone at, and cortical bone surrounding, the site of cartilage injury. This corresponded with a reduction in fi

SUBMITTER: Chan DD 

PROVIDER: S-EPMC5742076 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature