Tetraspanin CD9 Limits Mucosal Healing in Experimental Colitis.

ABSTRACT: Tetraspanins are a family of proteins with four transmembrane domains that associate between themselves and cluster with other partner proteins, conforming a distinct class of membrane domains, the tetraspanin-enriched microdomains (TEMs). These TEMs constitute macromolecular signaling platforms that regulate key processes in several cellular settings controlling signaling thresholds and avidity of receptors. In this study, we investigated the role of CD9, a tetraspanin that regulates major biological processes such as cell migration and immunological responses, in two mouse models of colitis that have been used to study the pathogenesis of inflammatory bowel disease (IBD). Previous in vitro studies revealed an important role in the interaction of leukocytes with inflamed endotheliu

SUBMITTER: Saiz ML 

PROVIDER: S-EPMC5742144 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature