Age-Associated Decline in Dendritic Cell Function and the Impact of Mediterranean Diet Intervention in Elderly Subjects.

ABSTRACT:

Introduction

Aging is accompanied by increased susceptibility to infection and age-associated chronic diseases. It is also associated with reduced vaccine responses, which is often attributed to immunosenescence and the functional decline of the immune system. Immunosenescence is characterized by a chronic, low-grade, inflammatory state termed inflammaging. Habitants of Mediterranean (MED) regions maintain good health into old age; often attributed to MED diets.

Hypothesis

Adoption of a MED-diet by elderly subjects, in Norfolk (UK), may improve immune responses of these individuals and in particular, dendritic cell (DC) function.

Experimental approach

A total of 120 elderly subjects (65-79 years old) recruited onto the Nu-AGE study, a multicenter European dietary stud

SUBMITTER: Clements SJ 

PROVIDER: S-EPMC5742184 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature