Bovine Immune Factors Underlying Tick Resistance: Integration and Future Directions.

ABSTRACT: The mechanisms underlying tick resistance within and between cattle breeds have been studied for decades. Several previous papers on bovine immune parameters contributing to tick resistance discussed findings across DNA, RNA, protein, cellular, and tissue levels. However, the differences between bovine host species, tick species and the experimental layouts were not always taken into account. This review aims to (a) give a comprehensive summary of studies investigating immune marker differences between cattle breeds with varying degrees of tick resistance, and (b) to integrate key findings and suggest hypotheses on likely immune-regulated pathways driving resistance. Experimental issues, which may have skewed conclusions, are highlighted. In future, improved experimental strategies will en

SUBMITTER: Robbertse L 

PROVIDER: S-EPMC5742187 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature