Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain.

ABSTRACT: Understanding amazingly complex brain functions and pathologies requires a complete cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral arteries and veins has been a century-old objective in neuroscience and neuropathology. Using micro-optical sectioning tomography (MOST) with a modified Nissl staining method, we acquired five mouse brain data sets containing arteries, veins, and microvessels. Based on the brain-wide vascular spatial structures and brain regions indicated by cytoarchitecture in one and the same mouse brain, we reconstructed and annotated the vascular system atlas of both arteries and veins of the whole mouse brain for the first time. The distributing patterns of the vascular system within the brain regions were acquired and our results s

SUBMITTER: Xiong B 

PROVIDER: S-EPMC5742197 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature