Geometrical Distribution of Cryptococcus neoformans Mediates Flower-Like Biofilm Development.

ABSTRACT: Microbial biofilms are highly structured and dynamic communities in which phenotypic diversification allows microorganisms to adapt to different environments under distinct conditions. The environmentally ubiquitous pathogen Cryptococcus neoformans colonizes many niches of the human body and implanted medical devices in the form of biofilms, an important virulence factor. A new approach was used to characterize the underlying geometrical distribution of C. neoformans cells during the adhesion stage of biofilm formation. Geometrical aspects of adhered cells were calculated from the Delaunay triangulation and Voronoi diagram obtained from scanning electron microscopy images (SEM). A correlation between increased biofilm formation and higher ordering of the underlying cell distr

SUBMITTER: Lopes W 

PROVIDER: S-EPMC5742216 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature