Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial.

ABSTRACT:

Objective

To evaluate the long-term effect of cumulative time exposed to Helicobacter pylori infection on the progression of gastric lesions.

Design

795 adults with precancerous gastric lesions were randomised to receive anti-H. pylori treatment at baseline. Gastric biopsies were obtained at baseline and at 3, 6, 12 and 16 years. A total of 456 individuals attended the 16-year visit. Cumulative time of H. pylori exposure was calculated as the number of years infected during follow-up. Multivariable logistic regression models were used to estimate the risk of progression to a more advanced diagnosis (versus no change/regression) as well as gastric cancer risk by intestinal metaplasia (IM) subtype. For a more detailed analysis of progression, we also used

SUBMITTER: Mera RM 

PROVIDER: S-EPMC5742304 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature