Anti-inflammatory Effects of Heme Oxygenase-1 Depend on Adenosine A_2A- and A_2B-Receptor Signaling in Acute Pulmonary Inflammation.

ABSTRACT: Acute pulmonary inflammation is still a frightening complication in intensive care units. In our previous study, we determined that heme oxygenase (HO)-1 had anti-inflammatory effects in pulmonary inflammation. Recent literature has emphasized a link between HO-1 and the nucleotide adenosine. Since adenosine A_2A- and A_2B-receptors play a pivotal role in pulmonary inflammation, we investigated their link to the enzyme HO-1. In a murine model of pulmonary inflammation, the activation of HO-1 by hemin significantly decreased polymorphonuclear leukocyte (PMN) migration into the lung. This anti-inflammatory reduction of PMN migration was abolished in A_2A- and A_2B-knockout mice. Administration of hemin significantly reduced chemokine levels in the BAL

SUBMITTER: Konrad FM 

PROVIDER: S-EPMC5742329 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature