Genetic Variants of RAMP2 and CLR are Associated with Stroke.

ABSTRACT:

Aim

Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions.

Methods

Using cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study in the baseline surveys, 14,087 participants

SUBMITTER: Koyama T 

PROVIDER: S-EPMC5742372 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature