Structural Insights into the Cytotoxic Mechanism of Vibrio parahaemolyticus PirA^vp and PirB^vp Toxins.

ABSTRACT: In aquaculture, shrimp farming is a popular field. The benefits of shrimp farming include a relatively short grow-out time, high sale price, and good cost recovery. However, outbreaks of serious diseases inflict serious losses, and acute hepatopancreatic necrosis disease (AHPND) is an emerging challenge to this industry. In South American white shrimp (Penaeus vannamei) and grass shrimp (Penaeus monodon), this disease has a 70-100% mortality. The pathogenic agent of AHPND is a specific strain of Vibrio parahaemolyticus which contains PirA^vp and PirB^vp toxins encoded in the pVA1 plasmid. PirA^vp and PirB^vp have been shown to cause the typical histological symptoms of AHPND in infected shrimps, and in

SUBMITTER: Lin SJ 

PROVIDER: S-EPMC5742833 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature