New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach.

ABSTRACT: Identifying ZIKV factors interfering with human host pathways represents a major challenge in understanding ZIKV tropism and pathogenesis. The integration of proteomic, gene expression and Protein-Protein Interactions (PPIs) established between ZIKV and human host proteins predicted by the OralInt algorithm identified 1898 interactions with medium or high score (≥0.7). Targets implicated in vesicular traffic and docking were identified. New receptors involved in endocytosis pathways as ZIKV entry targets, using both clathrin-dependent (17 receptors) and independent (10 receptors) pathways, are described. New targets used by the ZIKV to undermine the host's antiviral immune response are proposed based on predicted interactions established between the virus and host cell receptors and/or pro

SUBMITTER: Esteves E 

PROVIDER: S-EPMC5742907 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature