Amelioration of Clostridium difficile Infection in Mice by Dietary Supplementation With Indole-3-carbinol.

ABSTRACT:

Objective

To determine the therapeutic effects of dietary supplementation on Clostridium difficile infection (CDI).

Background

With limited treatment options, the rise of C. difficile-associated disease has spurred on the search for novel therapies. Recent data define a role for the aryl hydrocarbon receptor (AHR) and diet-derived AHR ligands in mucosal immunity. We investigated the efficacy of indole-3-carbinol (I3C), a dietary supplement, and AHR precursor ligand in a murine model of CDI.

Methods

C57BL/6 (B6), AHR, and AHR mice were placed on either grain-based or semipurified diets with or without I3C before and during CDI. Mice were followed clinically for a minimum of 6 days or euthanized between days 0 and 4 of inoculation for analysis of the inflammatory respon

SUBMITTER: Julliard W 

PROVIDER: S-EPMC5743052 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature