The transcription factor MEF2A fine-tunes gene expression in the atrial and ventricular chambers of the adult heart.

ABSTRACT: The distinct morphological and functional properties of the cardiac chambers arise from an elaborate developmental program involving cell lineage determination, morphogenesis, and dynamic spatiotemporal gene expression patterns. Although a number of transcription factors have been identified for proper gene regulation in the chambers, the complete transcriptional network that controls these patterns remains poorly defined. Previous studies have implicated the MEF2C transcription factor in the regulation of chamber-restricted enhancers. To better understand the mechanisms of MEF2-mediated regional gene regulation in the heart, we took advantage of MEF2A knock-out (KO) mice, a model that displays a predominantly ventricular chamber phenotype. Transcriptomic analysis of atrial and ventricular

SUBMITTER: Medrano JL 

PROVIDER: S-EPMC5743072 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature