Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions.

ABSTRACT: The bone is the main storage site for Ca²⁺ and Mg²⁺ ions in the mammalian body. Although investigations into Ca²⁺ signaling have progressed rapidly and led to better understanding of bone biology, the Mg²⁺ signaling pathway and associated molecules remain to be elucidated. Here, we investigated the role of a potential Mg²⁺ signaling-related lysosomal molecule, two-pore channel subtype 2 (TPC2), in osteoclast differentiation and bone remodeling. Previously, we found that under normal Mg²⁺ conditions, TPC2 promotes osteoclastogenesis. We observed that under low-Mg²⁺ conditions, TPC2 inhibited, rather than promoted, the osteoclast differentiation and that the phosphatidylinositol 3,5-bisphosphate (PI(3,5)P₂

SUBMITTER: Notomi T 

PROVIDER: S-EPMC5743074 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature