The human transient receptor potential vanilloid 3 channel is sensitized via the ERK pathway.

ABSTRACT: The transient receptor potential vanilloid 3 (TRPV3) channel is a Ca²⁺-permeable thermosensitive ion channel widely expressed in keratinocytes, where together with epidermal growth factor receptor (EGFR) forms a signaling complex regulating epidermal homeostasis. Proper signaling through this complex is achieved and maintained via several pathways in which TRPV3 activation is absolutely required. Results of recent studies have suggested that low-level constitutive activity of TRPV3 induces EGFR-dependent signaling that, in turn, amplifies TRPV3 via activation of the mitogen-activated protein kinase ERK in a positive feedback loop. Here, we explored the molecular mechanism that increases TRPV3 activity through EGFR activation. We used mutagenesis and whole-cell patch clamp experi

SUBMITTER: Vyklicka L 

PROVIDER: S-EPMC5743081 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature