Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.

ABSTRACT: Tumor cells display on their surface several molecular chaperones that normally reside in the endoplasmic reticulum. Because this display is unique to cancer cells, these chaperones are attractive targets for drug development. Previous epitope-mapping of autoantibodies (AutoAbs) from prostate cancer patients identified the 78-kDa glucose-regulated protein (GRP78) as one such target. Although we previously showed that anti-GRP78 AutoAbs increase tissue factor (TF) procoagulant activity on the surface of tumor cells, the direct effect of TF activation on tumor growth was not examined. In this study, we explore the interplay between the AutoAbs against cell surface-associated GRP78, TF expression/activity, and prostate cancer progression. First, we show that tumor GRP78 expression correlates

SUBMITTER: Al-Hashimi AA 

PROVIDER: S-EPMC5743090 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature