Why does cervical cancer occur in a state-of-the-art screening program?

ABSTRACT:

Background

The goal of cervical screening is to detect and treat precancers before some become cancer. We wanted to understand why, despite state-of-the-art methods, cervical cancers occured in relationship to programmatic performance at Kaiser Permanente Northern California (KPNC), where >1,000,000 women aged ≥30years have undergone cervical cancer screening by triennial HPV and cytology cotesting since 2003.

Methods

We reviewed clinical histories preceding cervical cancer diagnoses to assign "causes" of cancer. We calculated surrogate measures of programmatic effectiveness (precancers/(precancers and cancers)) and diagnostic yield (precancers and cancers per 1000 cotests), overall and by age at cotest (30-39, 40-49, and ≥50years).

Results

Cancer was rare and found m

SUBMITTER: Castle PE 

PROVIDER: S-EPMC5743197 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature