Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women.

ABSTRACT:

Objective

To investigate the association between bilateral oophorectomy and cognitive performance in healthy, older women.

Design

Retrospective analysis of clinical trial data.

Setting

Academic research institution.

Patient(s)

Healthy postmenopausal women without signs or symptoms of cardiovascular disease or diabetes (n = 926).

Intervention(s)

Randomized interventions (not the focus of this analysis) in analyzed trials included B-vitamins, soy isoflavones, oral estradiol, and matching placebos.

Main outcome measure(s)

Measures in five cognitive domains (executive functions, semantic memory, logical memory, visual memory, and verbal learning) and global cognitive function.

Result(s)

Using data from three clinical trials conducted under unif

SUBMITTER: Kurita K 

PROVIDER: S-EPMC5743432 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature