Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases.

ABSTRACT: Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasis to evaluate the efficacy of α-emitting radionuclides, ¹⁴⁹Tb, ²¹¹At, ²¹²Pb, ²¹³Bi and ²²⁵Ac; β-emitting radionuclides, ⁹⁰Y, ¹⁶¹Tb and ¹⁷⁷Lu; and Auger electron (AE)-emitters ⁶⁷Ga, ⁸⁹Zr, ¹¹¹In and ¹²⁴I, for targeted radionuclide therapy (TRT).

Methods

Histologic s

SUBMITTER: Falzone N 

PROVIDER: S-EPMC5743475 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature