Race, sex, and risk factors in radiographic worsening of knee osteoarthritis.

ABSTRACT:

Objectives

Characterize radiographic worsening in knee osteoarthritis (KOA) by race and sex over 4 years and evaluate the role of established risk factors in observed race/sex differences.

Methods

Whites (WHs) (694 males and 929 females) and African-Americans (AAs) (92 males and 167 females) at risk for radiographic KOA were eligible. Cox shared frailty models were used to estimate race and sex group differences in radiographic worsening, defined by Kellgren-Lawrence (K-L) and OARSI joint space narrowing (JSN). Mixed effect models for repeated measures were used to estimate race- and sex-specific mean medial and lateral fixed joint space width (fJSW) over 4 years of follow-up, as well as annual loss of fJSW.

Results

Risk of OARSI medial JSN grade worsening was higher

SUBMITTER: Vina ER 

PROVIDER: S-EPMC5743602 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature