Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies.

ABSTRACT:

Background

Early-life arsenic exposure has been associated with reduced cell-mediated immunity, but little is known about its effects on humoral immunity.

Objective

We evaluated whether prenatal and childhood arsenic exposure was associated with humoral immune function in school-aged children.

Methods

Children born in a prospective mother–child cohort in rural Bangladesh were immunized with measles, mumps, and rubella (MMR) vaccines at 9 years of age (n=525). Arsenic exposure was assessed in urine (U-As), from mothers during pregnancy and their children at 4.5 and 9 years of age. Total IgG (tIgG), tIgE, tIgA, and MMR-specific IgG concentrations were measured in plasma using immunoassays.

Results

Arsenic exposure was positively associated with child tIgG and tIg

SUBMITTER: Raqib R 

PROVIDER: S-EPMC5743616 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature