Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women.

ABSTRACT:

Background

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent synthetic chemicals that are widely used in industrial applications and often detectable in humans. In rats, PFASs can interfere with the estrous cycle. In humans, menstruation has been viewed as a proxy of female fecundity, and periodic menstruation plays a critical role in endometrial sloughing in the absence of pregnancy and in preparing for embryo implantation.

Objectives

We investigated the association between PFAS exposure and menstrual cycle characteristics in women who plan to become pregnant.

Methods

Plasma level of 10 PFASs was measured in 950 women who were attempting to become pregnant and recruited in two preconception care clinics in Shanghai, China, from August 2013 to April

SUBMITTER: Zhou W 

PROVIDER: S-EPMC5743639 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature