Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson's Disease Patients.

ABSTRACT: Regular exercise ameliorates motor symptoms in Parkinson's disease (PD). Here, we aimed to provide evidence that exercise brings additional benefits to the whole-body metabolism and skeletal muscle molecular and functional characteristics, which might help to explain exercise-induced improvements in the clinical state. 3-months supervised endurance/strength training was performed in early/mid-stage PD patients and age/gender-matched individuals (n = 11/11). The effects of exercise on resting energy expenditure (REE), glucose metabolism, adiposity, and muscle energy metabolism (³¹P-MRS) were evaluated and compared to non-exercising PD patients. Two muscle biopsies were taken to determine intervention-induced changes in fiber type, mitochondrial content, and expression of g

SUBMITTER: Krumpolec P 

PROVIDER: S-EPMC5743754 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature