Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms.

ABSTRACT:

Objectives

For patients with unresectable or metastatic thymic epithelial neoplasms, few therapy options are available and outcomes are poor. This case series demonstrates that the combination of capecitabine and celecoxib may be a promising therapeutic option for these patients.

Materials and methods

The current report describes the outcomes of 5 patients with thymic neoplasms treated on a drug-drug interaction study of capecitabine and celecoxib in patients with advanced solid malignancies (NCT01705106) conducted at the University of Chicago, plus a sixth patient treated with the same regimen outside of the protocol.

Results

Six patients with thymic neoplasms were treated with capecitabine 1000 mg/m twice daily and celecoxib 200 mg twice daily, day 1 to day 14 on a

SUBMITTER: Wood K 

PROVIDER: S-EPMC5743778 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature