Oxygen Self-Sufficient Amphiphilic Polypeptide Nanoparticles Encapsulating BODIPY for Potential Near Infrared Imaging-guided Photodynamic Therapy at Low Energy.

ABSTRACT: Near infrared (NIR) imaging-guided photodynamic therapy (PDT) is remarkable for its high-efficiency in "see and treat" field. However, hypoxia of cancer cell limits PDT dues to the low singlet oxygen yield. Here MnO₂ conjugated multifunctional polypeptide nanoparticles encapsulating photosensitizer BODIPY has been prepared via a one-step reaction, which can generate oxygen in cancer cytoplasm where rich of H₂O₂, following singlet oxygen by photosensitizer under NIR light irradiation. In vitro studies on HepG2 and 4T1 cancer cells revealed that the as-prepared nanoparticles obviously increase the cell suppression rate under hypoxia conditions, even exposed to an extremely low light energy density (25 mW/cm²). Meanwhile, excellent NIR fluore

SUBMITTER: Liu L 

PROVIDER: S-EPMC5743838 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature