Primary outcomes reporting in trials of paediatric type 1 diabetes mellitus: a systematic review.

ABSTRACT:

Objective

Our objective was to systematically review randomised clinical trials (RCTs) of paediatric type 1 diabetes mellitus (T1DM) to assess reporting of (1) primary outcome, (2) outcome measurement properties and (3) presence or absence of adverse events.

Methods

Electronic searches in MEDLINE, EMBASE, CINAHL, Cochrane SR and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were undertaken. The search period was between 2001 and 2017. English-language RCTs on children younger than 21 years with T1DM were selected. We excluded studies of diagnostic or screening tools, multiple phase studies, protocols, and follow-up or secondary analysis of data.

Results

Of 11 816 unique references, 231 T1DM RCTs were included. Of total 231 included studies, 11

SUBMITTER: Khanpour Ardestani S 

PROVIDER: S-EPMC5743897 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature