Abnormal Complement Activation and Inflammation in the Pathogenesis of Retinopathy of Prematurity.

ABSTRACT: Retinopathy of prematurity (ROP) is a neurovascular complication in preterm babies, leading to severe visual impairment, but the underlying mechanisms are yet unclear. The present study aimed at unraveling the molecular mechanisms underlying the pathogenesis of ROP. A comprehensive screening of candidate genes in preterms with ROP (n = 189) and no-ROP (n = 167) was undertaken to identify variants conferring disease susceptibility. Allele and genotype frequencies, linkage disequilibrium and haplotypes were analyzed to identify the ROP-associated variants. Variants in CFH (p = 2.94 × 10^-7), CFB (p = 1.71 × 10^-5), FBLN5 (p = 9.2 × 10^-4), CETP (p = 2.99 × 10^-5), and CXCR4 (<

SUBMITTER: Rathi S 

PROVIDER: S-EPMC5743907 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature