Latent human cytomegalovirus enhances HIV-1 infection in CD34⁺ progenitor cells.

ABSTRACT: Individuals who have been preinfected by human cytomegalovirus (HCMV) are more prone to AIDS disease progression after subsequent HIV-1 infection but the underlying mechanism remains elusive. HCMV is a ubiquitous DNA virus that commonly establishes lifelong latent infection in CD34⁺ progenitor cells, where latency-specific HCMV genes may modulate host restriction to HIV-1 infection. To test this hypothesis, we studied progenitor cells that are known to resist replicative HIV-1 infection because of the intrinsic expression of host restriction factors. Interestingly, in primary CD34⁺ cells undergoing latent HCMV infection, an enhanced level of HIV-1 proviral DNA and replication was observed as measured by digital polymerase chain reaction, quantitative polymerase chain

SUBMITTER: Cheung AKL 

PROVIDER: S-EPMC5744035 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature