A Roadmap for Tick-Borne Flavivirus Research in the "Omics" Era.

ABSTRACT: Tick-borne flaviviruses (TBFs) affect human health globally. Human vaccines provide protection against some TBFs, and antivirals are available, yet TBF-specific control strategies are limited. Advances in genomics offer hope to understand the viral complement transmitted by ticks, and to develop disruptive, data-driven technologies for virus detection, treatment, and control. The genome assemblies of Ixodes scapularis, the North American tick vector of the TBF, Powassan virus, and other tick vectors, are providing insights into tick biology and pathogen transmission and serve as nucleation points for expanded genomic research. Systems biology has yielded insights to the response of tick cells to viral infection at the transcript and protein level, and new protein targets for vaccine

SUBMITTER: Grabowski JM 

PROVIDER: S-EPMC5744076 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature