Continuous-Flow Production of Injectable Liposomes via a Microfluidic Approach.

ABSTRACT: Injectable liposomes are characterized by a suitable size and unique lipid mixtures, which require time-consuming and nonstraightforward production processes. The complexity of the manufacturing methods may affect liposome solubility, the phase transition temperatures of the membranes, the average particle size, and the associated particle size distribution, with a possible impact on the drug encapsulation and release. By leveraging the precise steady-state control over the mixing of miscible liquids and a highly efficient heat transfer, microfluidic technology has proved to be an effective and direct methodology to produce liposomes. This approach results particularly efficient in reducing the number of the sizing steps, when compared to standard industrial methods. Here, Microfluidic Hyd

SUBMITTER: Zizzari A 

PROVIDER: S-EPMC5744346 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature