Modulation of Radiation-induced Base Excision Repair Pathway Gene Expression by Melatonin.

ABSTRACT:

Objective

Approximately 70% of all cancer patients receive radiotherapy. Although radiotherapy is effective in killing cancer cells, it has adverse effects on normal cells as well. Melatonin (MLT) as a potent antioxidant and anti-inflammatory agent has been proposed to stimulate DNA repair capacity. We investigated the capability of MLT in the modification of radiation-induced DNA damage in rat peripheral blood cells.

Materials and methods

In this experimental study, male rats (n = 162) were divided into 27 groups (n = 6 in each group) including: irradiation only, vehicle only, vehicle with irradiation, 100 mg/kg MLT alone, 100 mg/kg MLT plus irradiation in 3 different time points, and control. Subsequently, they were irradiated with a single whole-body X-ray radiatio

SUBMITTER: Rezapoor S 

PROVIDER: S-EPMC5744453 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature