BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes.

ABSTRACT: In Oman, breast cancer is most common, representing approximately more than 25% of all cancers in women. Relatively younger populations of patients (25-40 years) present surprisingly with an aggressive phenotype and advanced tumor stages. In this study, we investigated differential gene expressions in Luminal A, Luminal B, triple-negative and Her2+ breast cancer subtypes and compared data to benign tumor samples. We identified a potential candidate gene BRIP1, showing differential expression in the four breast cancer subtypes examined, suggesting that BRIP1 has the profile of a useful diagnostic marker, suitable for targeted therapeutic intervention. RT-qPCR and Western blotting analysis showed higher BRIP1 expression in luminal samples as compared to triple-negative subtype patient's samp

SUBMITTER: Gupta I 

PROVIDER: S-EPMC5744628 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature