EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner.

ABSTRACT: Human sperm cell function must be precisely regulated to achieve natural fertilization. Progesterone released by the cumulus cells surrounding the egg induces a Ca²⁺ influx into human sperm cells via the CatSper Ca²⁺-channel and thereby controls sperm function. Multiple chemical UV filters have been shown to induce a Ca²⁺ influx through CatSper, thus mimicking the effect of progesterone on Ca²⁺ signaling. We hypothesized that these UV filters could also mimic the effect of progesterone on sperm function. We examined 29 UV filters allowed in sunscreens in the US and/or EU for their ability to affect acrosome reaction, penetration, hyperactivation and viability in human sperm cells. We found that, similar to progesterone, the UV filters 4-MBC, 3-BC

SUBMITTER: Rehfeld A 

PROVIDER: S-EPMC5744631 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature