International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin₁) and GPR1 (Chemerin₂) Nomenclature, Pharmacology, and Function.

ABSTRACT: Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous ligand for a G protein-coupled receptor encoded by the gene CMKLR1 (also known as ChemR23), and as a consequence the receptor protein was renamed the chemerin receptor in 2013. Since then, chemerin has been identified as the endogenous ligand for a second G protein-coupled receptor, encoded by the gene GPR1 Therefore, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification recommends that the official name of the receptor protein for chemokine-like receptor 1 (CMKLR1) is chemerin receptor 1, and G protein-coupled receptor 1 is chemerin receptor 2 to follow the convention of naming the receptor protein after the endogenous ligan

SUBMITTER: Kennedy AJ 

PROVIDER: S-EPMC5744648 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature