Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.

ABSTRACT:

Importance

Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8+ TILs by histotype and in relation to other clinical factors.

Objective

To define the prognostic role of CD8+ TILs in epithelial ovarian cancer.

Design, setting, and participants

This was a multicenter observational, prospective survival cohort study of the Ovarian Tumor Tissue Analysis Consortium. More than 5500 patients, including 3196 with high-grade serous ovarian carcinomas (HGSOCs), were followed prospectively for over 24 650 person-years.

Exposures

Following immunohistochemical analysis, CD8+ TILs were identified within the epithelial components of tumor islets. Patients were

SUBMITTER: Ovarian Tumor Tissue Analysis (OTTA) Consortium 

PROVIDER: S-EPMC5744673 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature