Abnormal cortical neural synchrony during working memory in schizophrenia.

ABSTRACT: OBJECTIVE:To better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information. METHODS:We examined time-frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM-related hemodynamic responses and individualized structural head-models. RESULTS:Compared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM-load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which wor

SUBMITTER: Kang SS 

PROVIDER: S-EPMC5745038 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature