The Optimal Age for Screening Adolescents and Young Adults Without Identified Risk Factors for HIV.

ABSTRACT:

Purpose

To assess the optimal age at which a one-time HIV screen should begin for adolescents and young adults (AYA) in the U.S. without identified HIV risk factors, incorporating clinical impact, costs, and cost-effectiveness.

Methods

We simulated HIV-uninfected 12-year-olds in the U.S. without identified risk factors who faced age-specific risks of HIV infection (.6-71.3/100,000PY). We modeled a one-time screen ($36) at age 15, 18, 21, 25, or 30, each in addition to current U.S. screening practices (30% screened by age 24). Outcomes included retention in care, virologic suppression, life expectancy, lifetime costs, and incremental cost-effectiveness ratios in $/year-of-life saved (YLS) from the health-care system perspective. In sensitivity analyses, we varied HIV incidenc

SUBMITTER: Neilan AM 

PROVIDER: S-EPMC5745059 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature