Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study.

ABSTRACT: Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical syndrome. Drug resistance means that empirical antibiotic therapy is often ineffective and currently no vaccine is available. The study objective was to identify risk factors for mortality among children presenting to hospital with invasive Salmonella disease in Africa. We conducted a prospective study enrolling consecutive children with microbiologically-confirmed invasive Salmonella disease admitted to Queen Elizabeth Central Hospital, Blantyre, in 2006. Data on clinical presentation, co-morbidities and outcome were used to identify children at risk of inpatient mortality through logistic-regression mod

SUBMITTER: MacLennan CA 

PROVIDER: S-EPMC5745124 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature