Coordination of platelet agonist signaling during the hemostatic response in vivo.

ABSTRACT: The local microenvironment within an evolving hemostatic plug shapes the distribution of soluble platelet agonists, resulting in a gradient of platelet activation. We previously showed that thrombin activity at a site of vascular injury is spatially restricted, resulting in robust activation of a subpopulation of platelets in the hemostatic plug core. In contrast, adenosine 5'-diphosphate (ADP)/P2Y₁₂ signaling contributes to the accumulation of partially activated, loosely packed platelets in a shell overlying the core. The contribution of the additional platelet agonists thromboxane A₂ (TxA₂) and epinephrine to this hierarchical organization was not previously shown. Using a combination of genetic and pharmacologic approaches coupled with real-time intravi

SUBMITTER: Shen J 

PROVIDER: S-EPMC5745130 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature