Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys.

ABSTRACT: Studies of both humans and non-human primates have demonstrated that aging is typically characterized by a decline in cognition that can occur as early as the fifth decade of life. Age-related changes in working memory are particularly evident and mediated, in part, by the prefrontal cortex, an area known to evidence age-related changes in myelin that is attributed to inflammation. In recent years, several nutraceuticals, including curcumin, by virtue of their anti-inflammatory and antioxidant effects, have received considerable attention as potential treatments for age-related cognitive decline and inflammation. Accordingly, we assessed for the first time in a non-human primate model of normal aging the efficacy of dietary intervention using the natural phenol curcumin to ameliorate the e

SUBMITTER: Moore TL 

PROVIDER: S-EPMC5745216 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature