Arterial Inflammation Detected With ¹⁸ F-Fluorodeoxyglucose-Positron Emission Tomography in Rheumatoid Arthritis.

ABSTRACT:

Objective

In addition to traditional risk factors, excess cardiovascular disease (CVD) in rheumatoid arthritis (RA) is attributed to enhanced vascular and/or systemic inflammation. In several small studies using ¹⁸ F-fluorodeoxyglucose-positron emission tomography/computed tomography (¹⁸ F-FDG-PET/CT) to directly assess vascular inflammation, FDG uptake was higher in RA patients than in controls. Using a substantially larger sample of RA patients, we sought to identify RA disease characteristics independently associated with vascular FDG uptake.

Methods

RA patients underwent cardiac FDG-PET/CT, with aortic inflammation assessed by quantification of FDG uptake in the ascending aorta, calculated as the mean and maximum (max) standardized uptake value (SUV

SUBMITTER: Geraldino-Pardilla L 

PROVIDER: S-EPMC5745261 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature