Regionally variant collagen alignment correlates with viscoelastic properties of the disc of the human temporomandibular joint.

ABSTRACT:

Objective

To determine the regionally variant quality of collagen alignment in human TMJ discs and its statistical correlation with viscoelastic properties.

Design

For quantitative analysis of the quality of collagen alignment, horizontal sections of human TMJ discs with Pricrosirius Red staining were imaged under circularly polarized microscopy. Mean angle and angular deviation of collagen fibers in each region were analyzed using a well-established automated image-processing for angular gradient. Instantaneous and relaxation moduli of each disc region were measured under stress-relaxation test both in tensile and compression. Then Spearman correlation analysis was performed between the angular deviation and the moduli. To understand the effect of glycosaminoglycans on the

SUBMITTER: Gutman S 

PROVIDER: S-EPMC5745264 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature