Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury.

ABSTRACT: There is increasing recognition that traumatic brain injury (TBI) may initiate long-term neurodegenerative processes, particularly chronic traumatic encephalopathy. However, insight into the mechanisms transforming an initial biomechanical injury into a neurodegenerative process remain elusive, partly as a consequence of the paucity of informative pre-clinical models. This study shows the functional, whole brain imaging and neuropathological consequences at up to one year survival from single severe TBI by controlled cortical impact in mice. TBI mice displayed persistent sensorimotor and cognitive deficits. Longitudinal T2 weighted magnetic resonance imaging (MRI) showed progressive ipsilateral (il) cortical, hippocampal and striatal volume loss, with diffusion tensor imaging demonstrating

SUBMITTER: Pischiutta F 

PROVIDER: S-EPMC5745280 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature