MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods.

ABSTRACT: Arthropods comprise the majority of all described animal species, and understanding their evolution is a central question in biology. Their developmental processes are under the precise control of distinct hormonal regulators, including the sesquiterpenoids juvenile hormone (JH) and methyl farnesoate. The control of the synthesis and mode of action of these hormones played important roles in the evolution of arthropods and their adaptation to diverse habitats. However, the precise roles of non-coding RNAs, such as microRNAs (miRNAs), controlling arthropod hormonal pathways are unknown. Here, we investigated the miRNA regulation of the expression of the juvenile hormone acid methyltransferase gene (JHAMT), which encodes a rate-determining sesquiterpenoid biosynthetic enzyme. Loss of functio

SUBMITTER: Qu Z 

PROVIDER: S-EPMC5745405 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature