Differential Effects of Superoxide Dismutase Mimetics after Mechanical Overload of Articular Cartilage.

ABSTRACT: Post-traumatic osteoarthritis can develop as a result of the initial mechanical impact causing the injury and also as a result of chronic changes in mechanical loading of the joint. Aberrant mechanical loading initiates excessive production of reactive oxygen species, oxidative damage, and stress that appears to damage mitochondria in the surviving chondrocytes. To probe the benefits of increasing superoxide removal with small molecular weight superoxide dismutase mimetics under severe loads, we applied both impact and overload injury scenarios to bovine osteochondral explants using characterized mechanical platforms with and without GC4403, MnTE-2-PyP, and MnTnBuOE-2-PyP. In impact scenarios, each of these mimetics provides some dose-dependent protection from cell death and loss of mitoch

SUBMITTER: Coleman MC 

PROVIDER: S-EPMC5745508 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature