Platelet CD40 Mediates Leukocyte Recruitment and Neointima Formation after Arterial Denudation Injury in Atherosclerosis-Prone Mice.

ABSTRACT: The role of platelets in the development of thrombosis and abrupt closure after angioplasty is well recognized. However, the direct impact of platelets on neointima formation after arterial injury remains undetermined. Herein, we show that neointima formation after carotid artery wire injury reduces markedly in CD40^-/- apolipoprotein E-deficient (apoE^-/-) mice but only slightly in CD40 ligand^-/-apoE^-/- mice, compared with apoE^-/- mice. Wild-type and CD40-deficient platelets were isolated from blood of apoE^-/- and CD40^-/-apoE^-/- mice, respectively. The i.v. injection of thrombin-activated platelets into CD40^-/-apoE^-/- mice was performed every 5 days, starting at 2 days before wire i

SUBMITTER: Jin R 

PROVIDER: S-EPMC5745524 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature